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Indinavir dosing information

Concomitant itraconazole 200 mg twice a day: Dose reduction of indinavir to 600 mg orally every 8 hours is recommended. When indinavir is taken with efavirenz, the beneficial effects of indinavir may decrease. Crixivan in combination with antiretroviral agents is indicated for the treatment of HIV infection. Viracept nelfinavir mesylate US prescribing information. order cheap fluoxetine shop europe fluoxetine

Moderate Be cautious with this combination

Patients with hemophilia: There have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitors. In some patients, additional factor VIII was required. In many of the reported cases, treatment with protease inhibitors was continued or restarted. A causal relationship between protease inhibitor therapy and these episodes has not been established. Gilead Sciences, Inc. February, 2016. What should I discuss with my healthcare provider before taking alosetron Lotronex?

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Therefore, -feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Etizolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Etizolam. Management: Consider use of lower etizolam doses when using this combination; specific recommendations concerning dose adjustment are not available. Monitor clinical response to the combination closely. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.

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Gilead Sciences, Inc. September, 2016. Table 3 effect of indinavir on other drugs. QUEtiapine: CYP3A4 Inhibitors Strong may increase the serum concentration of QUEtiapine. Management: In quetiapine treated patients, reduce the quetiapine dose to one sixth of the regular dose following strong CYP3A4 inhibitor initiation. In patients receiving strong CYP3A4 inhibitors, initiate quetiapine at the lowest dose and up-titrate as needed. Clinically significant adverse reactions, potentially leading to severe, life-threatening, or fatal events from greater exposures of concomitant medications.

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If you think you may be pregnant, contact your doctor right away. VIDEX EC or VIDEX didanosine may increase your risk for liver damage. Keep Crixivan capsules dry by leaving the small desiccant in the bottle. Keep the bottle closed. Kline MW, Fletcher CV, Harris AT et al. A pilot study of combination therapy with indinavir, stavudine d4T and didanosine ddI in children infected with the human immunodeficiency virus. J Pediatr. Your name may need to be listed on an antiviral pregnancy registry when you start using this medication. Meperidine. Protease Inhibitors may decrease the serum concentration of Meperidine. Concentrations of the toxic Normeperidine metabolite may be increased. Medication Guide for a complete list of ingredients in ONGLYZA. Cabazitaxel: CYP3A4 Inhibitors Strong may increase the serum concentration of Cabazitaxel. Management: Concurrent use of cabazitaxel with strong inhibitors of CYP3A4 should be avoided when possible. If such a combination must be used, consider a 25% reduction in the cabazitaxel dose.

Indinavir dosage

Further dose reductions may be needed in patients with impaired renal function. Consider alternative antimicrobial for any non-MAC infection. Reyataz atazanavir sulfate US prescribing information. Anon. HIV seroconversion after occupational exposure despite early prophylactic zidovudine therapy. Lancet. Varying degrees of HIV-1 cross-resistance have been observed between indinavir and other HIV-1 protease inhibitors. In studies with ritonavir, saquinavir, and amprenavir, the extent and spectrum of cross-resistance varied with the specific mutational patterns observed. In general, the degree of cross-resistance increased with the accumulation of resistance-associated amino acid substitutions. Elderly: Use with caution in elderly patients. Know the medicines you take. ZERIT stavudine should be avoided. PrednisoLONE Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of PrednisoLONE Systemic. Particular caution should be used when prescribing sildenafil, tadalafil, or vardenafil in patients receiving indinavir. Taking marijuana might decrease the effects of theophylline. But there isn't enough information to know if this is a big concern. How should I take ZERIT? ONGLYZA of 21 weeks. ketorolac

List of indinavir side effects

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take three doses a day, the doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your doctor. Fortovase saquinavir US prescribing information. Crixivan; renal insufficiency; renal failure; leukocyturia see crystalluria; dysuria. Asunaprevir: CYP3A4 Inhibitors Strong may increase the serum concentration of Asunaprevir. Frequency not always defined. Adverse reaction statistics have been compiled from studies including patients with advanced HIV disease. Consequently, it is difficult to distinguish reactions attributed to atovaquone from those caused by the underlying disease or a combination thereof. Your pharmacist can provide more information about alosetron. It is very important to continue taking this medication and other medications exactly as prescribed by your doctor. not take more or less of this drug than prescribed or stop taking it or other medicines even for a short time unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat, or worsen side effects. Collier AC, Coombs RW, Schoenfeld DA et al et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med. This medication was prescribed for your particular condition. Do not use it for any other condition or give it to anybody else. Keep Crixivan and all medicines out of the reach of children. If you suspect that more than the prescribed dose of this medicine has been taken, contact your local poison control center or emergency room immediately. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Hypersensitivity to indinavir or any component of the formulation; coadministration with alfuzosin, amiodarone, ergot derivatives dihydroergotamine, ergonovine, ergotamine, methylergonovine lovastatin, simvastatin, cisapride, lurasidone, pimozide, oral midazolam, triazolam, alprazolam, and sildenafil when used for the treatment of pulmonary arterial hypertension. Included as part of the PRECAUTIONS section.

What conditions does indinavir treat

Concomitant use of parenteral midazolam with CRIXIVAN may increase plasma concentrations of midazolam. CRIXIVAN will exacerbate the hyperbilirubinemia seen in neonates. These types of stones sometimes are also called if they grow large enough. Registered trademark of Pfizer, Inc. Registered trademark of Eli Lilly and Company. Median follow-up was 24 months. best price for mycelex

What are the possible side effects of indinavir

Sarilumab: May decrease the serum concentration of CYP3A4 Substrates. Whitehouse Station, NJ 08889, USA. The body breaks down antipyrine to get rid of it. Some chemicals in marijuana might decrease how quickly the body breaks down antipyrine. This might increase antipyrine levels in the body and increase its effects and side effects. Lapatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Lapatinib. Dose titration of ONGLYZA was not permitted. Ascher DP, Lucy MD. Indinavir sulfate renal toxicity in a pediatric hemophiliac with HIV infection. Ann Pharmacother. If it is almost time for your next dose, skip the missed dose. Patient may experience headache, nausea, vomiting, muscle pain, insomnia, sweating a lot, rhinitis, or rhinorrhea. Have patient report immediately to prescriber depression, thrush, cough, flu-like symptoms, or signs of liver problems dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or jaundice HCAHPS. Rilpivirine: CYP3A4 Inhibitors Strong may increase the serum concentration of Rilpivirine. Tasimelteon: CYP3A4 Inhibitors Strong may increase the serum concentration of Tasimelteon. Inhibits replication of HIV-1 and HIV-2 by interfering with HIV protease. Take the missed dose as soon as you remember. If you are more than 2 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Patients should be closely monitored for symptoms of pancreatitis. Piscitelli SC, Flexner C, Minor JR et al. Drug interactions in patients infected with human immunodeficiency virus. Clin Infect Dis. Estazolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Estazolam. Tibotec Therapeutics. Edurant rilpivirine tablets prescribing information. Raritan, NJ; 2011 May.

ZERIT should be considered

Children may be more sensitive to the side effects of this drug, especially effects on the kidney such as kidney stones. Burger DM, van Rossum AM, Hugen PW et al. Pharmacokinetics of the protease inhibitor indinavir in human immunodeficiency virus type 1-infected children. Antimicrob Agents Chemother. Tofacitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Tofacitinib. Management: Reduce the adult dose of tofacitinib to 5 mg daily in patients receiving strong CYP3A4 inhibitors. Diabetes: Changes in glucose tolerance, hyperglycemia, exacerbation of diabetes, DKA, and new-onset diabetes mellitus have been reported in patients receiving protease inhibitors. Prophylaxis should be initiated as soon as possible, within 72 hours of exposure. Indinavir plus ritonavir plus 2 NRTIs is one of the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis. buying oxcarbazepine in the uk

What should i avoid while taking indinavir

Public Health Service Centers for Disease Control and Prevention that HIV-infected mothers not breast-feed their infants to avoid risking postnatal transmission of HIV. CRIXIVAN. There is increased potential for sildenafil-associated adverse events which include visual disturbances, hypotension, prolonged erection, and syncope. Everolimus can make you more likely to get infections or may worsen any current infections. Therefore, well to prevent the spread of infection. Changes in body may occur while you are taking this medication such as increased fat in the upper back and areas, decreased fat in the arms and legs. The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of to reduce this side effect. If you take Crixivan with SUSTIVA, check with your doctor. Gerberding JL, Henderson DK. Management of occupational exposures to bloodborne pathogens: hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Clin Infect Dis. Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children, US Department of Health and Human Services HHS. Guidelines for the use of antiretroviral agents in pediatric HIV infection February 12, 2014. Updates may be available at HHS AIDS Information AIDSinfo website.

Indinavir drug interactions

The DHHS Panel on Clinical Practices for Treatment of HIV Infection does not recommend unboosted indinavir as initial therapy due to the frequency of administration and need to take on an empty stomach or with light meals. It may harm them. ONGLYZA inhibits DPP4 enzyme activity for a 24-hour period. Your doctor may want to run some blood test on you. Let your doctor know if you have any yellowing of the eyes or skin or any abdominal pain. It is not known whether Crixivan is dialyzable by peritoneal or hemodialysis. Product Information. Crixivan indinavir. AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor. The pharmacokinetic profiles of indinavir at this dose were not comparable to profiles previously observed in adults receiving the recommended dose see . Although viral suppression was observed in some of the 32 children who were followed on this regimen through 24 weeks, a substantially higher rate of nephrolithiasis was reported when compared to adult historical data see . Physicians considering the use of indinavir in pediatric patients without other protease inhibitor options should be aware of the limited data available in this population and the increased risk of nephrolithiasis. valsartan

In some patients, additional was required

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking first with your doctor. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Sherer R. Delta in the real world. Lancet. Dubé MP, Johnson DL, Currier JS et al. Protease inhibitor-associated hyperglycaemia. Lancet. ONGLYZA, with some reports occurring after the first dose. Tmax were not significantly altered by renal impairment. Retapamulin: CYP3A4 Inhibitors Strong may increase the serum concentration of Retapamulin. Management: Avoid this combination in patients less than 2 years old. No action is required in other populations. Carcinogenicity studies were conducted in mice and rats. Brexpiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of Brexpiprazole. Management: Reduce brexpiprazole dose to 50% of usual with a strong CYP3A4 inhibitor; reduce to 25% of usual if used with both a moderate CYP3A4 inhibitor and a CYP2D6 inhibitor, or if a strong CYP3A4 inhibitor is used in a CYP2D6 poor metabolizer.

Indinavir overdose

Crixivan Capsules are sensitive to moisture. Patients should be informed that Crixivan should be stored and used in the original container and the desiccant should remain in the bottle. ONGLYZA can be taken with or without food. Moderate Be cautious with this combination. Not all side effects for indinavir may be reported. You should always consult a doctor or healthcare professional for medical advice. Venlafaxine: May decrease the serum concentration of Indinavir. Erlotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Erlotinib. Management: Avoid use of this combination when possible. When the combination must be used, monitor the patient closely for the development of severe adverse reactions, and if such severe reactions occur, reduce the erlotinib dose in 50 mg decrements. How should I store ZERIT? Swollen kidneys due to blocked urine flow occurred rarely. It is very soluble in water and in methanol. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking indinavir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other medications can affect the removal of from your body, which may affect how trazodone works. Sherman KE. Mechanism of indinavir-induced hyperbilirubinemia. Trials and Post-Marketing Experience. theophylline brand name card

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Indinavir side effects

Following 1-hour IV infusion

Crixivan. There is increased potential for sildenafil-associated adverse events which include visual disturbances, hypotension, prolonged erection, and syncope. Silodosin: CYP3A4 Inhibitors Strong may increase the serum concentration of Silodosin. Some birth control pills contain estrogen. Marijuana may have effects that counteract estrogen. Taking marijuana along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with marijuana, use an additional form of birth control such as a condom. clomid

Use of indinavir

Wurtz R. Abnormal fat distribution and use of protease inhibitors. Lancet. DOCEtaxel: CYP3A4 Inhibitors Strong may increase the serum concentration of DOCEtaxel. Management: Avoid the concomitant use of docetaxel and strong CYP3A4 inhibitors when possible. If combined use is unavoidable, consider a 50% docetaxel dose reduction and monitor for increased docetaxel toxicities. Lacosamide: CYP3A4 Inhibitors Strong may increase the serum concentration of Lacosamide.

Major Adverse Cardiac Event MACE

Using indinavir with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Older adults may be more sensitive to the side effects of this drug. Which drugs or supplements interact with indinavir? Repaglinide: CYP3A4 Inhibitors Strong may increase the serum concentration of Repaglinide. Management: The addition of a CYP2C8 inhibitor to this drug combination may substantially increase the magnitude of increase in repaglinide exposure.

How should i store indinavir

Consult appropriate product labeling. Indinavir should not be used in patients receiving avanafil for treatment of erectile dysfunction 188 or sildenafil for treatment of PAH. ONGLYZA and seek medical advice promptly.

Fugh-Berman A. Herb-drug interactions. Lancet. Bristol-Myers Squibb. Videx EC didanosine delayed-release capsules enteric-coated beadlets prescribing information. Princeton, NJ; 2011 Nov. Tacrolimus Topical: Protease Inhibitors may decrease the metabolism of Tacrolimus Topical. Maness LJ, Blair DC, Newman N, Coyle TE "Elevation of platelet counts associated with indinavir treatment in human immunodeficiency virus-infected patients. Diabetes and high blood sugar hyperglycemia have occurred in patients taking protease inhibitors. In some of these patients, this led to ketoacidosis, a serious condition caused by poorly controlled blood sugar. Some patients had diabetes before starting protease inhibitors, others did not. Some patients required adjustments to their diabetes medication. Others needed new diabetes medication.

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